Author's response to reviews Title: Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children Authors: Aurora Mejía-Benítez ([email protected])
نویسندگان
چکیده
Aurora Mejía-Benítez ([email protected]) Miguel Klünder-Klünder ([email protected]) Loic Yengo ([email protected]) David Meyre ([email protected]) Celia Aradillas ([email protected]) Esperanza Cruz ([email protected]) Elva Pérez-Luque ([email protected]) Juan M Malacara ([email protected]) Maria E Garay ([email protected]) Jesús Peralta-Romero ([email protected]) Samuel Flores-Huerta ([email protected]) Jaime García-Mena ([email protected]) Philippe Froguel ([email protected]) Miguel Cruz ([email protected]) Amélie Bonnefond ([email protected])
منابع مشابه
Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults
BACKGROUND Several studies have identified multiple obesity-associated loci mainly in European populations. However, their contribution to obesity in other ethnicities such as Mexicans is largely unknown. The aim of this study was to examine 26 obesity-associated single-nucleotide polymorphisms (SNP) in a sample of Mexican mestizos. METHODS 9 SNPs in biological candidate genes showing replica...
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OBJECTIVE Recent genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/generalized obesity. In this study, we aimed to examine the associations of identified SNPs with risk of central obesity in a child population from China. METHODS We genotyped 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265,...
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Obesity has become a major public health concern worldwide. Obesity is a complex disease influenced by both genetic and environmental factors. Epidemiological studies have indicated that environmental factors, such as excessive energy intake and lack of physical activity, might contribute to the development of obesity. Genetic factors also play an important role in the pathogenesis of obesity. ...
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BACKGROUND High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background. OBJECTIVE The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birt...
متن کاملReplication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1). Here we extend those studies by examining associations with adiposity and type 2 diabetes in Swedish adults. The nine single nucleotide polymorphisms (SNPs) were genotyped in 3885 non-diabetic and 1038 diabetic individuals with a...
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